Cellendes
Natural, Synthetic
Dextran-based hydrogel
Dextran is covalently crosslinked by CD-Link via the Michael addition reaction. CD-Link is a metalloproteinase (MMP)-cleavable peptide conjugated to polyethylene glycol (PEG).
3D
Spheroids, Other
HaCaT (RRID:CVCL_0038)
HCT 116 (RRID:CVCL_0291)
Hep-G2 (RRID:CVCL_0027)
HL-60 (RRID:CVCL_0002)
MCF-7 (RRID:CVCL_0031)
MDA-MB-231 (RRID:CVCL_0062)
NCI-H838 (RRID:CVCL_1594)
NIH 3T3 (RRID:CVCL_0594)
PANC-1 (RRID:CVCL_0480)
U-87MG ATCC (RRID:CVCL_0022)
U-937 (RRID:CVCL_0007)
HCT 116 (RRID:CVCL_0291)
Hep-G2 (RRID:CVCL_0027)
HL-60 (RRID:CVCL_0002)
MCF-7 (RRID:CVCL_0031)
MDA-MB-231 (RRID:CVCL_0062)
NCI-H838 (RRID:CVCL_1594)
NIH 3T3 (RRID:CVCL_0594)
PANC-1 (RRID:CVCL_0480)
U-87MG ATCC (RRID:CVCL_0022)
U-937 (RRID:CVCL_0007)
Breast cancer organoids & CAR T cells & MDA-MB-231 (CVCL_0062) & ROR1− fibroblasts & T cells
Dermal fibroblasts & HCT 116 (CVCL_0291) & HL-60 (CVCL_0002) & Human umbilical vein endothelial cells (HUVECs) & NCI-H838 (CVCL_1594) & U-937 (CVCL_0007)
Dermal fibroblasts & MCF-7 (RRID:CVCL_0031)
HaCaT (CVCL_0038) & HL-60 (CVCL_0002) & MCF-7 (CVCL_0031) & NCI-H838 (CVCL_1594) & U-937 (CVCL_0007)
Melanocytes & Peripheral blood mononuclear cells (PBMCs) & T cells
Dermal fibroblasts & HCT 116 (CVCL_0291) & HL-60 (CVCL_0002) & Human umbilical vein endothelial cells (HUVECs) & NCI-H838 (CVCL_1594) & U-937 (CVCL_0007)
Dermal fibroblasts & MCF-7 (RRID:CVCL_0031)
HaCaT (CVCL_0038) & HL-60 (CVCL_0002) & MCF-7 (CVCL_0031) & NCI-H838 (CVCL_1594) & U-937 (CVCL_0007)
Melanocytes & Peripheral blood mononuclear cells (PBMCs) & T cells
Yes
Yes
Yes
Specified
G’ = 20−10,000 Pa
Yes
Thiol-mediated conjugation. 3-D Life peptides or custom-made peptides with thiol groups can be covalently attached to the hydrogel.
Yes
Enzymatic digestion by 3-D Life Dextranase.
Yes
No
Yes
Cell extravasation assay, Chemotaxis assay, Cytokine release assay, High-throughput screening, Organ-on-a-chip model, RGD, Tumour infiltration assay